RAD140: a promising SARM?

RAD140, commonly known as Testolone, has garnered significant popularity within the bodybuilding community in recent years due to its impressive ability to promote lean mass and provide lean, dry gains. Let’s delve into its mechanism of action, potential benefits and uses, as well as its side effects profile.

What is RAD140

RAD 140, is a remarkable compound belonging to the category of Selective Androgen Receptor Modulators (SARMs). SARMs are a class of compounds designed to selectively target specific androgen receptors in the body. RAD 140, in particular, has shown considerable potential in promoting muscle growth, enhancing strength, and improving athletic performance.

RAD140 is considered to be as potent as LGD 4033 in terms of muscle building ability. For a side by side comparison go check this guide.

Mechanism of Action:

RAD 140 selectively binds to androgen receptors located in muscle and bone tissues. However, as with most SARMs, this tissue selectivity diminishes at higher dosages.

By stimulating anabolic processes in muscle and bone tissues, RAD 140 promotes increased protein synthesis, resulting in enhanced muscle growth and potentially improved bone density.

Due to its high selectivity for muscle and bone tissues, RAD 140 is believed to offer greater anabolic effects with fewer androgenic-related side effects compared to traditional steroids. However, practical application has shown that this might not always hold true, especially at dosages commonly used in the bodybuilding community.

Benefits of RAD 140:

Increased Muscle Mass: RAD 140 promotes the development of lean muscle mass, contributing to a lean and defined physique. Users often report a more sculpted appearance with enhanced muscle definition.

Enhanced Strength and Performance: RAD 140 improves strength levels and endurance, enabling users to push harder during workouts. Users experience notable gains in strength and increased stamina during prolonged training sessions. While it may not match the strength and mass gains of stronger SARMs like S23 or YK11, it is comparable to LGD 4033 in this regard.

Fat Loss: RAD 140 elevates the metabolic rate, allowing individuals to consume more calories during bulking phases without significant fat gain. As a result, RAD 140 can be an effective choice for cutting phases.

Improved Recovery: RAD 140 is believed to expedite the recovery process by supporting muscle repair and reducing muscle damage, leading to enhanced post-workout recovery.


Increase in Blood Pressure: Some users may experience a drastic increase in resting blood pressure, even at lower dosages (e.g., 10mg per day).

Impaired Lipid Profile: RAD 140 is known to negatively impact lipid levels in bloodwork.

Androgenic Side Effects: Some users may encounter androgenic side effects, such as heightened aggression, increased libido, and hair loss.

HPTA Suppression: RAD 140 can significantly suppress the Hypothalamic-Pituitary-Testicular Axis (HPTA), necessitating the use of a test base if running the compound for more than four weeks continuously.

SHBG Crash: RAD 140 can lower Sex Hormone Binding Globulin (SHBG), leading to increased free testosterone. This effect may cause an unexpected “spillover” effect in individuals already supplementing with testosterone.

Liver Toxicity: Anecdotally, RAD 140 has shown some liver toxicity, especially when used in bodybuilding dosages. Therefore, it is advisable not to use this compound continuously for more than 12 weeks.